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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DKC1
All Species:
29.39
Human Site:
S422
Identified Species:
46.19
UniProt:
O60832
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60832
NP_001354.1
514
57674
S422
E
Y
V
D
Y
S
E
S
A
K
K
E
V
V
A
Chimpanzee
Pan troglodytes
XP_521345
595
65925
S503
E
Y
V
D
Y
S
E
S
A
K
K
E
V
V
A
Rhesus Macaque
Macaca mulatta
XP_001090867
597
66468
T505
E
Y
V
D
Y
S
E
T
A
K
K
E
V
V
A
Dog
Lupus familis
XP_549382
517
57997
S422
E
Y
V
D
Y
S
D
S
A
K
K
E
V
V
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9ESX5
509
57483
S422
D
Y
I
D
Y
S
D
S
G
K
N
T
L
V
T
Rat
Rattus norvegicus
P40615
509
56597
S423
D
Y
V
D
Y
S
D
S
S
K
K
A
T
A
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514686
519
58453
T424
D
Y
V
D
Y
R
A
T
V
K
K
E
P
V
T
Chicken
Gallus gallus
Q5ZJH9
516
58132
S420
E
Y
V
D
Y
R
E
S
S
K
K
E
A
A
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001028279
506
56658
T417
G
Y
V
D
Y
S
T
T
K
V
K
K
G
G
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O44081
508
56812
K420
G
Y
V
D
Y
N
A
K
K
P
A
A
Q
E
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17919
445
50192
D362
K
R
V
I
M
E
R
D
V
Y
G
R
K
W
G
Sea Urchin
Strong. purpuratus
XP_001187533
541
60439
K415
G
Y
Q
D
Y
S
V
K
K
E
E
A
K
P
E
Poplar Tree
Populus trichocarpa
XP_002323264
482
54054
W399
N
D
N
T
P
H
E
W
A
R
N
L
V
L
P
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LD90
565
63008
G413
N
V
V
L
P
T
G
G
D
A
I
I
A
G
A
Baker's Yeast
Sacchar. cerevisiae
P33322
483
54686
A392
E
Y
V
P
L
D
N
A
E
Q
S
T
S
S
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.3
85.5
89.9
N.A.
90
83.2
N.A.
85.3
81.4
N.A.
74.7
N.A.
64.7
N.A.
58.7
64.8
Protein Similarity:
100
85.3
86
93.6
N.A.
93.1
90.8
N.A.
88.8
89.9
N.A.
85.4
N.A.
77.6
N.A.
71.4
77
P-Site Identity:
100
100
93.3
93.3
N.A.
46.6
60
N.A.
53.3
66.6
N.A.
40
N.A.
26.6
N.A.
6.6
26.6
P-Site Similarity:
100
100
100
100
N.A.
73.3
80
N.A.
66.6
73.3
N.A.
53.3
N.A.
33.3
N.A.
13.3
40
Percent
Protein Identity:
61.2
N.A.
N.A.
57.5
57.9
N.A.
Protein Similarity:
76.4
N.A.
N.A.
73.4
71.9
N.A.
P-Site Identity:
20
N.A.
N.A.
13.3
20
N.A.
P-Site Similarity:
33.3
N.A.
N.A.
20
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
14
7
34
7
7
20
14
14
40
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
20
7
0
74
0
7
20
7
7
0
0
0
0
0
0
% D
% Glu:
40
0
0
0
0
7
34
0
7
7
7
40
0
7
14
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
20
0
0
0
0
0
7
7
7
0
7
0
7
14
7
% G
% His:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
7
7
0
0
0
0
0
0
7
7
0
0
0
% I
% Lys:
7
0
0
0
0
0
0
14
20
54
54
7
14
0
7
% K
% Leu:
0
0
0
7
7
0
0
0
0
0
0
7
7
7
0
% L
% Met:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
14
0
7
0
0
7
7
0
0
0
14
0
0
0
0
% N
% Pro:
0
0
0
7
14
0
0
0
0
7
0
0
7
7
7
% P
% Gln:
0
0
7
0
0
0
0
0
0
7
0
0
7
0
0
% Q
% Arg:
0
7
0
0
0
14
7
0
0
7
0
7
0
0
0
% R
% Ser:
0
0
0
0
0
54
0
40
14
0
7
0
7
7
7
% S
% Thr:
0
0
0
7
0
7
7
20
0
0
0
14
7
0
14
% T
% Val:
0
7
80
0
0
0
7
0
14
7
0
0
34
40
7
% V
% Trp:
0
0
0
0
0
0
0
7
0
0
0
0
0
7
0
% W
% Tyr:
0
80
0
0
74
0
0
0
0
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _